4 cores with Grade Group 4 or 5 - PSA>40 ng/mL - Primary Gleason pattern 5 - 2 or 3 high-risk features For this patient: cT3b-cT4: Yes - rectal examination shows possible extracapsular invasion, which qualifies as clinical stage T3 Grade Group 4 or 5: Yes - Gleason 4+4=8 corresponds to Grade Group 4 PSA>40 ng/mL: No - PSA is 18 ng/mL Primary..." /> Qwen Studio